Insufficient Vitamin D Can Raise Miscarriage Risk: Lancet

Apart from boosting bone health, vitamin D also plays an important role in maintaining pregnancy and preventing miscarriage, a study has shown.

The findings, appearing in the journal The Lancet Diabetes and Endocrinology, showed that women who had sufficient preconception vitamin D concentrations were 10 per cent more likely to become pregnant and 15 per cent more likely to have a successful birth, compared to those with insufficient concentrations of the vitamin.

Among women who became pregnant, each 10 nanogram per millilitre increase in preconception vitamin D was associated with a 12 per cent lower risk of pregnancy loss.

"Our findings suggest that vitamin D may play a protective role in pregnancy," said lead investigator Sunni L. Mumford, in the Epidemiology Branch at National Institutes of Health's Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) in Maryland, US.

Previous studies have shown that women who have higher levels of vitamin D before undergoing in-vitro fertilisation (IVF) have higher pregnancy rates than those with lower levels.

For the new study, the team included 1,200 women, whose blood levels of vitamin D were tested for roughly before pregnancy and again at the eighth week of pregnancy. Researchers defined a vitamin D level of below 30 nanograms per millilitre as insufficient.

Vitamin D levels in the eighth week of pregnancy were not linked to pregnancy loss.

However, the study does not prove cause and effect, the researchers said, emphasising the need to further determine whether providing vitamin D to women at risk for pregnancy loss could increase their chances for pregnancy and live birth.